A change or variation. The quality of being changeable; mutability. One of the sudden or unexpected changes or shifts often encountered in one's life, activities, or surroundings. Often used in the plural. See Synonyms at difficulty.
[Latin vicissitd, from vicissim, in turn, probably from vics, pl. of *vix, change. See weik-2 in Indo-European Roots.]
This was also used in the Utne editorial piece:
May your next seven years unfold in ways that surprise and amaze you. May you find ways to put your gifts to service. May you laugh and cry and dance with the vicissitudes of life.
Side note: What a lovely paragraph!